The Eagles came into the competition as favourites after being demoted from the Europa League last summer.
They clinched the first major honour in club history by winning the FA Cup last season, and just over a year on can establish themselves as European champions for the first time.
The Eagles were beaten 2-1 by Arsenal in their final match of the domestic campaign, but will be confident of victory as they face Rayo Vallecano, who finished eighth in La Liga, missing out on qualification for this competition by a single point, and beat Chelsea’s sister club Strasbourg in the quarter-finals of this competition.
Crystal Palace do come into the match with two injury concerns, though, with Chris Richards and Adam Wharton both nursing ankle injuries.
The pair were seen in training ahead of the match, though Richards went inside early, and Glasner has confirmed that the pair are available for selection, but kept his cards close to his chest when asked if either could start.
Nonetheless, history beckons for the Eagles in Leipzig.
How to watch Crystal Palace vs Rayo Vallecano
TV channel: In the UK, the game will be televised live on TNT Sports 1, with coverage starting at 6.30pm BST ahead of an 8pm kick-off.
Live stream: TNT Sports subscribers can also catch the contest live online via the HBO Max app and website.
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